A histologic review of 27 patients with lichen planopilaris - 24/04/13
Abstract |
Background |
Lichen planopilaris (LPP) is a potential trichologic emergency that can result in permanent scarring alopecia. Histopathology is a key component of the diagnostic work-up.
Objective |
To identify the key histologic features that characterize LPP in order to facilitate diagnosis, ultimately leading to improved patient outcomes.
Methods |
Scalp biopsy specimens from 27 confirmed cases of LPP were reviewed in a blinded fashion to determine diagnostically helpful histologic features.
Results |
Absence of arrector pili muscles and sebaceous glands, a perivascular and perifollicular lymphocytic infiltrate in the reticular dermis and mucinous perifollicular fibroplasia within the upper dermis with absence of interfollicular mucin, and superficial perifollicular wedge-shaped scarring were characterizing features.
Limitations |
Sample size was limited, given that biopsy specimens were taken from lesions at varying stages of evolution and findings vary with disease stage.
Conclusions |
This study confirms many previously reported histologic features and highlights new characterizing features of mucinous perifollicular fibroplasia.
Le texte complet de cet article est disponible en PDF.Abbreviations used : DLE, LPP, NAHRS
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 59 - N° 1
P. 91-98 - juillet 2008 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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