Atopic dermatitis–like presentation of graft-versus-host disease: A novel form of chronic cutaneous graft-versus-host disease - 14/06/13
Abstract |
Background |
Graft-versus-host disease (GVHD) is a systemic disease, and skin is often one of the target organs. An atopic dermatitis (AD)-like presentation has never to our knowledge been reported.
Objective |
We sought to describe an AD-like presentation of cutaneous GVHD.
Methods |
Data on 11 patients with an AD-like presentation of GVHD were collected. The clinical and laboratory findings were retrospectively studied.
Results |
All 11 patients developed skin lesions after hematopoietic stem-cell transplantation. The skin lesions occurred between 2 to 12 months after transplantation. Eight patients received their transplant from a first-degree family member; 3 received their transplant from an unrelated donor. The skin lesions were pruritic and suggestive of AD, whereas the histology showed features of AD and GVHD. The lesions responded to topical and systemic anti-inflammatory and immunosuppressive therapy and phototherapy.
Limitations |
The number of patients is small and the study is retrospective.
Conclusions |
AD-like GVHD might represent a novel form of chronic cutaneous GVHD and responds well to treatment.
Le texte complet de cet article est disponible en PDF.Key words : atopic dermatitis, graft-versus-host disease
Abbreviations used : AD, GVHD, HSCT, NB, UV
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 69 - N° 1
P. 34-39 - juillet 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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