Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma - 14/06/13
Abstract |
Background |
The use of many of the standard skin-directed mycosis fungoides (MF) therapies on facial skin may be limited by site-specific increased risks of side effects, excessive inflammation, and ocular toxicity.
Objective |
Our study aimed to describe the levels of erythema, scale, and induration of facial lesions in MF before and after low-dose high-dose-rate surface applicator brachytherapy and to examine the overall clinical response to brachytherapy.
Methods |
A total of 23 facial MF lesions in 10 patients were treated with high-dose-rate brachytherapy doses of 4 Gy per session for a total of 2 fractions at our multidisciplinary cutaneous oncology clinic between August 17, 2009, and March 12, 2012.
Results |
In all 23 lesions, dramatic clinical improvement was observed. Patients were followed up for a median of 6.3 months. No recurrences were reported in the follow-up period.
Limitations |
Long-term follow-up is lacking. Reassessment of all included patients at annual intervals for a period of at least 5 years is the authors' goal.
Conclusion |
Low-dose high-dose-rate brachytherapy using custom-made surface molds is a highly efficacious therapy in the treatment of facial lesions in MF.
Le texte complet de cet article est disponible en PDF.Key words : convex surface, cutaneous T-cell lymphoma, facial lesions, mycosis fungoides, photon brachytherapy, radiation, skin-directed therapy
Plan
The first 2 authors contributed equally to this article. |
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Supported by a grant from the German Research Foundation (No. GU1271/2-1 to Dr Guenova). |
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Conflicts of interest: None declared. |
Vol 69 - N° 1
P. 61-65 - juillet 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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