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A prospective, interventional assessment of psoriasis quality of life using a nonskin-specific validated instrument that allows comparison with other major medical conditions - 17/07/13

Doi : 10.1016/j.jaad.2012.10.009 
Tina Bhutani, MD a, , Tejas Patel, BA b, Bonnie Koo, MD c, Thao Nguyen, MD d, Judith Hong, MD a, John Koo, MD a
a Department of Dermatology, University of California, San Francisco, California 
b Chicago Medical School, North Chicago, Illinois 
c Department of Medicine, North Shore University Hospital, Manhasset, New York 
d Department of Medicine, University of Washington, Seattle, Washington 

Reprint requests: Tina Bhutani, MD, University of California, San Francisco, Psoriasis and Skin Treatment Center, 515 Spruce St, San Francisco, CA 94118.

Abstract

Background

Psoriasis significantly impacts patients’ quality of life.

Objectives

The purpose of this study was to prospectively assess the quality-of-life impact of treatment for moderate to severe plaque psoriasis by using a validated quality-of-life psychometric instrument that has been widely used in nondermatologic settings.

Methods

In all, 32 patients with moderate to severe plaque psoriasis received 24 weeks of adalimumab treatment. Patients completed the Psychological General Well-Being (PGWB) Index, which evaluates 6 domains including anxiety and depression. The primary end point was the change in total PGWB score at weeks 12 and 24 of adalimumab treatment compared with baseline.

Results

Statistically significant improvement in the total PGWB score was documented by week 4. By week 24, all 6 PGWB domains showed statistically significant improvement from the pretreatment baseline.

Limitations

One limitation of this study is that the comparison between our psoriasis data and PGWB data from other major medical conditions was not conducted in a head-to-head manner. Another limitation is that we did not have a controlled (placebo) arm.

Conclusion

Based on PGWB scores, patients with untreated psoriasis have as much impairment in psychological well-being as patients with other major medical diseases including breast cancer, coronary artery disease, congestive heart failure, and diabetes and that potent intervention improves psychological well-being to where it is comparable with that of patients with asymptomatic hypertension. A prompt intervention with an effective dermatologic treatment is not only critical, but capable of restoring the physical and psychological well-being of patients with psoriasis.

Le texte complet de cet article est disponible en PDF.

Key words : adalimumab, biologics, psoriasis, Psychological General Well-Being Index, quality of life

Abbreviations used : PASI, PGWB, QoL


Plan


 Partially funded by a research grant from Abbott, Abbott Park, IL; a research grant from the Doris Duke Charitable Foundation; and a National Psoriasis Foundation Medical Dermatology grant.
 Disclosure: Dr John Koo is a consultant, investigator, and speaker for Abbott. Drs Bhutani, Bonnie Koo, Nguyen, and Hong, and Mr Patel have no conflicts of interest to declare.


© 2013  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 69 - N° 2

P. e79-e88 - août 2013 Retour au numéro
Article précédent Article précédent
  • Factors associated with female pattern hair loss and its prevalence in Taiwanese women: A community-based survey
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| Article suivant Article suivant
  • Physician survey of dermatology quality reporting initiatives in Colorado
  • Bryan T. Alvarez, Cory A. Dunnick, Robert P. Dellavalle

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