Reduced expression of TRIF in chronic HBV infected Iranian patients - 30/10/13
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Summary |
Background and aims |
TRIF is one of the main intracellular adaptor proteins required for TLR3 and 4 signaling. Abnormal gene expression of TRIF may lead to abrogated immune responses against viral infections including hepatitis B infection. The aim of this study was to identify the mRNA levels of TRIF in PBMCs isolated from chronic HBV (CHB) infected patients.
Material and methods |
mRNA was isolated from 63 CHB patients and 60 healthy controls and transcript levels of TRIF were examined in parallel with beta-actin (as housekeeping gene) using Real-Time PCR techniques.
Results |
Our results demonstrated that expression of TRIF was significantly decreased in PBMCs isolated from CHB patients when compared to healthy controls.
Conclusions |
Based on the results reported here, it seems that CHB patients are unable to express appropriate levels of the TRIF gene, which may attenuate TLR3 and 4 signaling subsequent to HBV infection. Our results suggest a possible mechanism, which may explain why hepatitis B infection is stable in CHB patients.
Le texte complet de cet article est disponible en PDF.Abbreviations : HBV, PBMC, TRIF, TLR, PAMP, MYD88, IRAK1, TRAF6, NF-κB, IRF3
Plan
Vol 37 - N° 5
P. 491-495 - novembre 2013 Retour au numéro
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