The objective of Clinical Decision Support (CDSS) systems coupled with Computerised Physician Order Entry (CPOE) systems is to improve patient safety. However, there are still issues to be considered to improve the quality of CDSS, especially the difficulty to share the knowledge developed by institutions or healthcare organisations and to exploit it for other medical application. The aim of the Patient Safety through Intelligent Procedures (PSIP) project is to propose innovative tools to generate and provide relevant knowledge to healthcare professionals and patients for Adverse Drug Events (ADE) prevention. The particularity of the PSIP project is to consider the share of knowledge and the interoperability of medical applications via the elaboration of a Global Knowledge Platform (GKP). In this paper, we present the different components of the PSIP GKP and we show its implementation through three medical applications: a web application, an Electronic Health Record (EHR) and a CPOE.