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Research gaps in psoriasis: Opportunities for future studies - 18/12/13

Doi : 10.1016/j.jaad.2013.08.042 
Caitriona Ryan, MD a, Neil J. Korman, MD, PhD b, Joel M. Gelfand, MD, MSCE c, k, Henry W. Lim, MD d, Craig A. Elmets, MD e, Steven R. Feldman, MD, PhD f, Alice B. Gottlieb, MD, PhD g, John Y.M. Koo, MD h, Mark Lebwohl, MD i, Craig L. Leonardi, MD j, Abby S. Van Voorhees, MD k, Reva Bhushan, PhD l, , Alan Menter, MD a
a Psoriasis Research Center, Baylor University Medical Center, Dallas, Texas 
b Department of Dermatology, Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, Ohio 
k Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 
c Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 
d Department of Dermatology, Henry Ford Hospital, Detroit, Michigan 
e Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 
f Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 
g Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts 
h Department of Dermatology, University of California–San Francisco, California 
i Department of Dermatology, Mount Sinai School of Medicine, New York, New York 
j Saint Louis University, St Louis, Missouri 
l American Academy of Dermatology, Schaumburg, Illinois 

Reprint requests: Reva Bhushan, PhD, American Academy of Dermatology, 930 E Woodfield Rd, Schaumburg, IL 60173.

Abstract

Over the past 2 decades, considerable progress has been made to further elucidate the complex pathogenesis of psoriasis, facilitating the development of a new armamentarium of more effective, targeted therapies. Despite these important advances, substantial deficits remain in our understanding of psoriasis and its treatment, necessitating further research in many areas. In the sixth section of the American Academy of Dermatology Psoriasis Guidelines of Care, gaps in research and care were identified. We discuss the most important gaps in research that currently exist and make suggestions for studies that should be performed to address these deficits. These encompass both basic science and clinical research studies, including large, prospective epidemiologic studies to determine the true prevalence and natural history of psoriasis; further molecular studies in patients with psoriatic and psoriatic arthritis to understand the function of psoriasis susceptibility genes and to identify novel therapeutic targets; studies to examine the role of environmental factors in the development of psoriasis; further investigation of the relationship between psoriasis and cardiometabolic disease; studies that examine the role of adjunctive therapies such as psychological interventions in appropriate patient groups; and finally, studies to identify biomarkers of disease severity and treatment response to optimize patient therapy.

Le texte complet de cet article est disponible en PDF.

Key words : adjunctive therapies, biologics, cardiovascular disease, comorbidities in psoriasis, comparative studies, disease severity, environmental factors in the development of psoriasis, future research studies, methotrexate, molecular studies in psoriatic and psoriatic arthritis, pathomechanisms and genetics of psoriasis, phototherapy, psoriasis, psoriasis guidelines, psoriasis treatment, psoriatic arthritis, psychological, research gaps, therapeutic targets, topical therapies

Abbreviations used : ACR, CRP, FDA, IFN, IL, MACE, MI, NB, NIH, PsA, RA, RCT, TNF, UV, VEGF


Plan


 Funding sources: None.
 The authors' conflict of interest/disclosure statements appear at the end of the article.


© 2013  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 70 - N° 1

P. 146-167 - janvier 2014 Retour au numéro
Article précédent Article précédent
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  • From the Medical Board of the National Psoriasis Foundation: The risk of cardiovascular disease in individuals with psoriasis and the potential impact of current therapies
  • Jeremy Hugh, Abby S. Van Voorhees, Rajiv I. Nijhawan, Jerry Bagel, Mark Lebwohl, Andrew Blauvelt, Sylvia Hsu, Jeffrey M. Weinberg

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