Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas - 18/12/13
Abstract |
Background |
Some patients develop a disproportionate number of cutaneous squamous cell carcinomas (SCCs) on their lower extremity (LE).
Objective |
We sought to characterize the clinical features, treatment, and outcome in patients who develop multiple LE SCCs.
Methods |
We identified 22 patients with 4 or more biopsy-diagnosed LE SCCs during a 4.5-year study period. The location, size, treatment, and clinical outcome of each LE SCC were recorded.
Results |
Of the 22 patients studied, 18 were female. Of the 360 SCCs our patients developed, 260 (72.2%) were on the LE. The incidence of SCCs in these patients was nearly 7 times greater than the incidence of basal cell carcinoma in the same patients.
Limitations |
The number of patients is small and limits definitive conclusions about prevalence of SCCs on the LE in the general population.
Conclusions |
LE SCCs are a distinct subset of cutaneous SCCs and may have distinctive clinical features and biologic behavior requiring additional study.
Le texte complet de cet article est disponible en PDF.Key words : basal cell carcinoma, carcinogen, epidemiology, female, immunosuppression, leg, lower extremity, squamous cell carcinoma, ultraviolet radiation
Abbreviations used : BCC, LE, MCS, SCC, UV
Plan
| Supported by a Yale University School of Medicine Research Fellowship. |
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| Conflicts of interest: None declared. |
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| Reprints not available from the authors. |
Vol 70 - N° 1
P. 70-74 - janvier 2014 Retour au numéro
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