An open-label study of anakinra for the treatment of moderate to severe hidradenitis suppurativa - 16/01/14
, Shivani V. Tripathi, MD, Tien V. Nguyen, MD, Mariela Pauli, MS, Michael D. Rosenblum, MD, PhDAbstract |
Background |
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by sterile abscesses and fistulae predominantly affecting the axillae and groin. Various biologic agents have been attempted for HS, but there is still no definitive treatment.
Objectives |
We sought to evaluate the efficacy, safety, and tolerability of anakinra in the treatment of moderate to severe HS.
Methods |
Six patients with moderate to severe HS were enrolled in an open-label study with all patients receiving active treatment for 8 weeks with an additional 8 weeks of follow-up off therapy.
Results |
The 5 patients who completed the 8-week therapy showed a significant mean decrease in their modified Sartorius score of 34.8 points. The physician and patient global assessment of overall activity showed significant reductions between baseline and 8 weeks of therapy: 45.8 points and 35.6 points, respectively. The Dermatology Life Quality Index showed a significant reduction after 8 weeks of treatment with anakinra. Functional T-cell analysis revealed that patients had increased percentages of CD3+ T cells in lesional skin compared with nonlesional skin before therapy.
Limitations |
The limited number of patients and lack of control group are limitations.
Conclusions |
Anakinra demonstrated decreased HS disease activity by both objective and subjective measures.
Le texte complet de cet article est disponible en PDF.Key words : anakinra, inflammation, interleukin-1, hidradenitis suppurativa, T cells, treatment
Abbreviations used : CI, DLQI, HS, IL, Th, TNF, VAS
Plan
| Swedish Orphan Biovitrum AB provided study drug but all other funding was from internal research funds. |
|
| Disclosure: Dr Leslie has served as a consultant and is on the speaker’s bureau for Novartis Pharmaceuticals. Drs Tripathi, Nguyen, and Rosenblum, and Ms Pauli have no conflicts of interest to declare. |
Vol 70 - N° 2
P. 243-251 - février 2014 Retour au numéro
Article précédent
- Change of Address
- The methotrexate polyglutamate assay supports the efficacy of methotrexate for severe inflammatory skin disease in children
- Syed I. Rahman, Elaine Siegfried, Katherine H. Flanagan, Eric S. Armbrecht
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?