Anti-tumor effect of paeonol via regulating NF-?B, AKT and MAPKs activation: A quick review - 18/02/14

Doi : 10.1016/j.bionut.2013.08.002

Jing Wu ^a, Xia Xue ^a, Zhen Wu ^b, Heng-Li Zhao ^c, Hong-Mei Cao ^d, De-Qing Sun ^a, Rong-Mei Wang ^a, Jing Sun ^a, Ying Liu ^a, Rui-Chen Guo ^e,^⁎
^a Department of Pharmacy, The Second Hospital of Shandong University, Jinan, Shandong 250033, China
^b Clinical laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, China
^c Institute of Clinical Pharmacology, The Second Hospital of Shandong University, Jinan, Shandong 250033, China
^d Department of Pharmacy, People's Hospital of Zhangqiu, Jinan, Shandong 250200, China
^e Institute of Clinical Pharmacology, Qi Lu Hospital of Shandong University, Jinan, Shandong 250012, China

^⁎Corresponding author. Tel.: (fax): +86 531 821 696 36.

Abstract

Paeonol, an active component extracted from Chinese herbs, Moutan cortex and Cynanchum paniculatum, has been characterized for its various biological activities, including sedation, hypnosis, anti-inflammatory, anti-allergic, and immunoregulation. Recently, paeonol was investigated to regulate the signalling pathways, including NF-κB, PI3K/PTEN/AKT and ERK/JNK/P38/MAPKs activations, which have been proposed to inhibit apoptosis and induce proliferation in human cancer. In this review, we summarized the literature documenting the involvement of the relationship between anti-tumor effect of paeonol and those signalling pathways.

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Keywords : Paeonol, Anti-tumor, NF-κB, PI3K/PTEN/AKT, ERK/JNK/P38/MAPKs

Plan

Introduction

Apoptosis and signalling pathway

Paeonol regulates NF-κB, AKT, MAPKs activation

NF-κB pathway

PI3K/PTEN/AKT pathway

MAPKs pathways

Conclusion

Disclosure of interest

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Vol 4 - N° 1

P. 9-14 - janvier 2014 Retour au numéro

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Anti-tumor effect of paeonol via regulating NF-?B, AKT and MAPKs activation: A quick review - 18/02/14

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