Treatment of extramammary Paget disease of the vulva with imiquimod: A retrospective, multicenter study by the German Colposcopy Network - 14/03/14
, Philipp Sörgel, MD b, Andreas Clad, MD, PhD c, Friederike Gieseking, MD d, Karin Maass-Poppenhusen, MD e, Ralph J. Lellé, MD, PhD f, Philipp Harter, MD g, Nina Buttmann, MPH h, Karl Ulrich Petry, MD, PhD aAbstract |
Background |
Extramammary Paget disease (EMPD) is a very rare genital neoplasia associated with a high frequency of local recurrences. Surgical excision is the standard treatment, but results in mutilating procedures in patients with advanced or recurrent disease. Case reports have shown clinical responses to imiquimod in patients with EMPD, but this therapy has not been evaluated systematically.
Objective |
The aim of this study was to evaluate imiquimod as local treatment of first-time and recurrent EMPD.
Methods |
All cases of biopsy-proven EMPD of the vulva treated within the German Colposcopy Network or other institutions specializing in vulvar diseases in Germany were included in this retrospective analysis.
Results |
A total of 21 women with EMPD treated with imiquimod were identified: 11 (52.4%) achieved complete response, 6 (28.6%) achieved partial response, and there were no cases of progressive disease. The dose and duration of imiquimod differed between patients. The mean duration of treatment exceeded 16 weeks in women achieving complete response.
Limitations |
EMPD is rare and this retrospective study is limited by the small number of patients identified.
Conclusion |
When associated cancers and invasive growth are excluded, imiquimod appears to be a useful treatment option for recurrent EMPD and may avoid extensive mutilating surgical treatment.
Le texte complet de cet article est disponible en PDF.Key words : clinical response, extramammary Paget disease of the vulva, imiquimod, tissue-sparing surgery, treatment of recurrences
Abbreviations used : CR, EMPD, PR
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
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| The authors dedicate this manuscript to their friend and colleague Andreas Clad who died at an early age in August 2013. |
Vol 70 - N° 4
P. 644-650 - avril 2014 Retour au numéro
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