Effect of confounding cofactors on responses to pollens during natural season versus pollen challenge chamber exposure - 27/04/14
, Nathan Harper, BS b, c, Weijing He, MD b, c, Charles P. Andrews, MD a, Cynthia G. Rather, CCRC a, Daniel A. Ramirez, MD a, Sunil K. Ahuja, MD b, c, d, eAbstract |
Background |
The severity of allergic rhinoconjunctivitis (AR) symptomatology elicited after exposure to pollen in the absence versus the presence of confounding cofactors, such as in a pollen challenge chamber (PCC) and the natural pollinating season, respectively, might differ.
Objective |
We sought to determine the correlation of AR severity in the natural season versus out-of-season PCC exposures.
Methods |
Twenty-four Virginia live oak (VLO)–positive, 14 VLO-negative, 16 mountain cedar (MC)−positive, 8 MC-negative, and 26 ragweed-positive participants recorded AR symptoms (total symptom score [TSS]) during the VLO, MC, and ragweed pollinating seasons and during 2 consecutive PCC exposures of 3 hours each to these pollens separately.
Results |
The TSSs recorded before the natural season were higher than the pre-PCC values. This prepriming was greater among VLO+ than MC+ participants, and it blunted further increases in TSSs during the VLO natural season. Nonatopic participants were nonreactive in the PCC. There was wide variation in the level of AR symptomatology after exposure to VLO, MC, or ragweed pollen in the PCC. Prepriming formed the basis for higher AR responses observed in the natural season than in the PCC, resulting in the identification of distinct PCC/natural season endophenotypes and a partial correlation between the TSSs recorded in the natural season versus those recorded in the PCC (r = 0.34, 0.54, and 0.65 for VLO+, MC+, and ragweed-positive participants, respectively).
Conclusions |
Prepriming in the natural pollinating season might obscure the true correlation between AR severity in the natural season versus the PCC. By mitigating confounding cofactors, PCC exposures have utility for evaluation of novel AR therapeutics.
Le texte complet de cet article est disponible en PDF.Key words : Allergy, pollen, challenge, confounding, season
Abbreviations used : AR, MC, PCC, TSS, VLO
Plan
| S.K.A. received support from the following sources: the Doris Duke Distinguished Clinical Scientist Award, the Burroughs Wellcome Clinical Scientist in Translational Research Award, the Max and Minnie Tomerlin Voelcker Scholar Award, and the Center for Personalized Medicine at the South Texas Veterans Health Care System. |
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| Disclosure of potential conflict of interest: R. L. Jacobs is co-owner/primary investigator of Biogenics Research Chamber and owner/primary investigator of Biogenics Research Institute. C. P. Andrews is owner/primary investigator of Diagnostics Research Group and co-owner/primary investigator of Biogenics Research Chamber. C. G. Rather is employed by Biogenics Research Chamber. D. A. Ramirez is co-owner/primary investigator of Biogenics Research Chamber. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 133 - N° 5
P. 1340 - mai 2014 Retour au numéro
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