Histiocytoid Sweet syndrome may indicate leukemia cutis: A novel application of fluorescence in situ hybridization - 14/05/14
Abstract |
Background |
In patients with malignancy-associated Sweet syndrome, a thorough evaluation for leukemia cutis should be considered.
Objective |
We sought to describe the clinicopathologic characteristics of histiocytoid Sweet syndrome.
Methods |
We retrospectively identified patients with histiocytoid Sweet syndrome at our institution from January 1992 through December 2010. We evaluated the underlying cutaneous infiltrate using immunohistochemistry and fluorescence in situ hybridization.
Results |
We re-evaluated all 22 patients with hematologic malignancy–associated Sweet syndrome. Six patients had a monocytoid infiltrate that was consistent with histiocytoid Sweet syndrome; subsequent evaluation of these patients demonstrated cytogenetic abnormalities on prior bone-marrow biopsy specimens. Fluorescence in situ hybridization analysis was feasible in cutaneous specimens from 5 of the 6 patients and demonstrated the same cytogenetic abnormalities that were identified on prior bone-marrow biopsy specimens in 4 patients. Therefore, these 4 patients may have had a form of leukemia cutis.
Limitations |
This was a retrospective study.
Conclusion |
For patients with histiocytoid Sweet syndrome, an underlying hematologic malignancy, and a monocytoid infiltrate on biopsy specimen, fluorescence in situ hybridization of the cutaneous infiltrate may be beneficial to identify cytogenetic abnormalities that may indicate leukemia cutis.
Le texte complet de cet article est disponible en PDF.Key words : cytogenetic abnormalities, fluorescence in situ hybridization analysis, histiocytoid Sweet syndrome, leukemia cutis, malignancy-associated Sweet syndrome, Sweet syndrome
Abbreviation used : FISH, MLL
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 70 - N° 6
P. 1021-1027 - juin 2014 Retour au numéro
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