The objective of this study was to investigate the antioxidant potential of turmeric (TMR) (1% turmeric-diet) against the renal toxicity induced by deltamethrin (DLM) (41ppm) in rats. Male Wistar rats were randomly divided into four groups of sex each: a control group and three treated groups during 7 weeks with TMR alone and DLM administrated either alone in drinking water for DLM group or co-administred with TMR for DLM+TMR group. Results showed that DLM caused a significant reduction in body weight and kidney absolute and relative weight and decreased antioxidant enzyme activity accompanied by significant (P<0.001) increased renal MDA, serum urea and creatinine levels compared to control. Histopathologically, DLM caused dilatation of proximal tubules, tubular cell desquamation, inflammatory cell infiltration, degeneration and necrosis. TMR co-administration significantly restored oxidative enzymes activity, serum biochemistry, MDA level and histological alterations caused by DLM. However, all these changes were monitored by Fourier transform–infrared spectroscopy (FT–IR) technique, reflecting the alteration in the biomolecules due to the oxidative stress caused by DLM intoxication. While, TMR co-administration brought them near to the control, it can be concluded that TMR has beneficial influences and could be able to antagonize DLM caused oxidative stress, changes in serum biochemistry and histopathological alterations in male Wister rats.