Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: A chart-verified case-control analysis - 15/11/14
Abstract |
Background |
Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving intertriginous skin. Previous epidemiologic studies have been limited by small sample size.
Objective |
We sought to describe the prevalence and comorbidities of HS in a large patient care database.
Methods |
In this retrospective case-control study, we chart-validated all patients within a hospital database who received at least 1 billing code for HS between 1980 and 2013. Verified cases were matched with controls based on age, gender, and race. Prevalences of a priori selected comorbidities were compared between HS and control groups.
Results |
A total of 2292 patients at Massachusetts General Hospital received at least 1 code for HS. A total of 1776 cases had a validated diagnosis of HS, yielding a prevalence of 0.08%. In unadjusted analysis, all comorbidities were diagnosed significantly more in HS compared with control including (in rank order of likelihood): smoking, arthropathies, dyslipidemia, polycystic ovarian syndrome, psychiatric disorders, obesity, drug dependence, hypertension, diabetes, thyroid disease, alcohol dependence, and lymphoma (all P < .01).
Limitations |
Control subjects were not validated for absence of HS and comorbidity validation was not performed for either group.
Conclusions |
Our results highlights the high comorbidity burden of patients with HS compared with matched control subjects.
Le texte complet de cet article est disponible en PDF.Key words : acne inversa, cardiovascular disease, comorbidities, hidradenitis, hidradenitis suppurativa, lymphoma, metabolic syndrome, obesity, prevalence
Abbreviations used : CI, HS, ICD-9, OR, PCOS, RPDR, SCC
Plan
Dr Shlyankevich has partial fellowship funding from Janssen. |
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Disclosure: Dr Kimball has served as an investigator and consultant for Abbvie. Dr Shlyankevich has partial fellowship funding from Janssen. Ms Chen and Ms Kim have no conflicts of interest to declare. |
Vol 71 - N° 6
P. 1144-1150 - décembre 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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