Médecine

Paramédical

Autres domaines


S'abonner

Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis - 15/11/14

Doi : 10.1016/j.jaad.2014.08.004 
Mei-Ju Ko, MD, PhD a, c, e, Yu-Sen Peng, MD, PhD b, d, Hung-Yuan Chen, MD b, d, Shih-Ping Hsu, MD, PhD b, d, Mei-Fen Pai, MD b, d, Ju-Yeh Yang, MD, MS b, d, Su-Ying Wen, MD a, Shiou-Hwa Jee, MD, PhD c, Hon-Yen Wu, MD, PhD b, d, f, , Hsien-Ching Chiu, MD c
a Department of Dermatology, Taipei City Hospital, Taipei, Taiwan 
b Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan 
c Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan 
d Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan 
e Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan 
f Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan 

Reprint requests: Hon-Yen Wu, MD, PhD, Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, No. 21, Section 2, Nanya South Rd, Banciao District, New Taipei City 220, Taiwan.

Abstract

Background

Interleukin (IL)-31 induces severe pruritus and dermatitis in transgenic mice, and is associated with many itching skin diseases.

Objective

We sought to investigate the association of serum IL-31 levels with uremic pruritus in patients undergoing hemodialysis.

Methods

Patients receiving maintenance hemodialysis in a referral medical center were recruited. Serum IL-31 levels were determined by the enzyme-linked immunosorbent assay methodology. The various characteristics of pruritus were assessed using an interview questionnaire.

Results

Among the 178 study participants, 34.8% had uremic pruritus. The patients with pruritus had higher serum IL-31 levels than those without pruritus symptoms (median 8.68 [first quartile 0.43, third quartile 35.04] vs 4.91 [0, 15.78], P = .04). A multivariate linear regression analysis showed that higher serum levels of IL-31, high-sensitivity C-reactive protein, and alanine transaminase, and a lower dialysis dose assessed by Kt/V, were independent predictors for higher pruritus intensity. The generalized additive model also showed a positive exposure-response relationship between serum levels of IL-31 and visual analog scale scores of pruritus intensity.

Limitations

The cause-effect relationship between IL-31 and uremic pruritus could not be assessed by the cross-sectional study design.

Conclusion

IL-31 may play an important role in the pathophysiology of uremic pruritus.

Le texte complet de cet article est disponible en PDF.

Key words : cytokines, hemodialysis, interleukin-31, itching, pruritogen, uremic pruritus

Abbreviations used : hsCRP, IL, VAS


Plan


 Supported by research grants to Dr Ko from the National Science Council, Taiwan (NSC 102-2314-B-532-002); Department of Health, Taipei City Government, Taipei, Taiwan (10101-62-052; 10201-62-009); and Taipei City Hospital, Ren-Ai branch, Taipei, Taiwan (No.19, 2013).
 Drs Wu and Chiu contributed equally to this collaborative research work as corresponding authors.
 Conflicts of interest: None declared.


© 2014  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 71 - N° 6

P. 1151 - décembre 2014 Retour au numéro
Article précédent Article précédent
  • Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: A chart-verified case-control analysis
  • Julia Shlyankevich, Allison J. Chen, Grace E. Kim, Alexandra B. Kimball
| Article suivant Article suivant
  • Utility of serum thymus and activation-regulated chemokine as a biomarker for monitoring of atopic dermatitis severity
  • Janneke Landheer, Marjolein de Bruin-Weller, Chantal Boonacker, DirkJan Hijnen, Carla Bruijnzeel-Koomen, Heike Röckmann

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

;

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.