Interleukin (IL)-31 induces severe pruritus and dermatitis in transgenic mice, and is associated with many itching skin diseases.
We sought to investigate the association of serum IL-31 levels with uremic pruritus in patients undergoing hemodialysis.
Patients receiving maintenance hemodialysis in a referral medical center were recruited. Serum IL-31 levels were determined by the enzyme-linked immunosorbent assay methodology. The various characteristics of pruritus were assessed using an interview questionnaire.
Among the 178 study participants, 34.8% had uremic pruritus. The patients with pruritus had higher serum IL-31 levels than those without pruritus symptoms (median 8.68 [first quartile 0.43, third quartile 35.04] vs 4.91 [0, 15.78], P = .04). A multivariate linear regression analysis showed that higher serum levels of IL-31, high-sensitivity C-reactive protein, and alanine transaminase, and a lower dialysis dose assessed by Kt/V, were independent predictors for higher pruritus intensity. The generalized additive model also showed a positive exposure-response relationship between serum levels of IL-31 and visual analog scale scores of pruritus intensity.
The cause-effect relationship between IL-31 and uremic pruritus could not be assessed by the cross-sectional study design.
IL-31 may play an important role in the pathophysiology of uremic pruritus.Le texte complet de cet article est disponible en PDF.
Key words : cytokines, hemodialysis, interleukin-31, itching, pruritogen, uremic pruritus
Abbreviations used : hsCRP, IL, VAS
| Supported by research grants to Dr Ko from the National Science Council, Taiwan (NSC 102-2314-B-532-002); Department of Health, Taipei City Government, Taipei, Taiwan (10101-62-052; 10201-62-009); and Taipei City Hospital, Ren-Ai branch, Taipei, Taiwan (No.19, 2013).
| Drs Wu and Chiu contributed equally to this collaborative research work as corresponding authors.
| Conflicts of interest: None declared.