Autologous iliac crest bone graft has been long considered the gold standard for spine fusion but is associated with various adverse effects. New sources, such as adipose derived mesenchymal stem cells (AMSCs) have recently emerged and demonstrated to be an alternative for bone tissue engineering. Our purpose is to analyze the effectiveness and safety of this implantation procedure.
Materials and methods
Between 2012 and 2013, eleven patients (4 men, 7 women) (AMSCs group: AMSCs+DBM, n=3; control group: DBM alone, n=8) with a lytic or degenerative spondylolisthesis underwent transforaminal lumbar interbody fusion (TLIF). Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) assessment were completed preoperatively and at 12months after surgery. Fusion status was assessed by radiologists.
At 12months, an early fusion rate of 67% (2/3) was achieved for the AMSCs group and 87.5% (7/8) for the control group. Mean VAS scores decreased, respectively, from 8.3 to 2.5 in group AMSCs and from 6.5 to 3.3 in group control. Mean ODI improved from 47% to 33% in group AMSCs and from 32% to 26% in group control. No major neurological complications occurred.
Our preliminary analysis seems to provide similar results than our routine procedure. Further research, is needed to demonstrate AMSCs as an effective alternative for bone regeneration.Le texte complet de cet article est disponible en PDF.