Consumption of vegetables may reduce the risk of liver cancer: Results from a meta-analysis of case-control and cohort studies - 05/02/15
, Dan Luo d, De-hua Hu b, e, Ping Mao a, Wen-zhao Xie a, b, Xiao-feng He c, Wei Kan c, f, Yun Wang cBienvenue sur EM-consulte, la référence des professionnels de santé.
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Summary |
Purpose |
We conducted a meta-analysis of all published case-control and cohort studies to evaluate the relationship between vegetables intake and liver cancer risk.
Methods |
We searched for cohort and case–control studies published before February 2014, using Pubmed and Cochrane Library Central database. Pooled relative risk (RR) estimates and corresponding 95% confidence interval (CI) were calculated using the inverse-variance method.
Results |
Eight case-control studies and one cohort study were included in this meta-analysis, involving a total of 136,425 subjects and 1349 liver cancer cases. Finally, we observed a statistically significant protective effect of vegetables consumption on liver cancer (RR=0.78, 95% CI [0.62, 0.99]). In the present meta-analysis, no publication bias was observed among studies using Begg's P value (P=0.532); Egger's (P=0.180) test, which suggested there was no evidence of publication bias.
Conclusions |
Our results suggest that vegetables consumption may reduce the risk of liver cancer. More prospective cohort studies with larger sample size, well-controlled confounding factors are warranted to further evaluate the association.
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Vol 39 - N° 1
P. 45-51 - février 2015 Retour au numéro
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