Correlation of early-onset hidradenitis suppurativa with stronger genetic susceptibility and more widespread involvement - 15/02/15
, Hessel H. van der Zee, MD, PhD a, Jurr Boer, MD, PhD c, Errol P. Prens, MD, PhD a, bAbstract |
Background |
The reported mean age of onset of hidradenitis suppurativa (HS) is between 20 and 24 years. Prepubertal onset is thought to be rare.
Objective |
We sought to determine the prevalence of early-onset HS and to compare clinical characteristics between early-onset and normal-onset HS in a retrospective study.
Methods |
Data were collected from 855 patients with HS. Early-onset HS was defined as onset before the thirteenth birthday. Clinical characteristics were analyzed in relation to the age of onset.
Results |
In all, 66 patients (7.7%) reported early-onset HS. A family history for HS was significantly higher in early-onset patients (55.6% vs 34.2%; odds ratio 2.1, 95% confidence interval 1.2-3.6, P = .006). They developed inflammatory lesions at more body sites than patients with normal-onset HS (odds ratio 3.0, 95% confidence interval 1.8-4.9, P < .001). Distribution of the Hurley stages of severity showed no differences between the 2 groups (odds ratio 1.1, 95% confidence interval 0.7-1.8, P = .72).
Limitations |
Some data were based on patient-reported information.
Conclusion |
Early-onset HS occurs more frequently than previously believed. Patients with early-onset HS often report a family history for HS and develop lesions at more body sites.
Le texte complet de cet article est disponible en PDF.Key words : acne ectopica, acne inversa, age of onset, disease extent, disease severity, early onset, family history, genetic predisposition, hidradenitis suppurativa
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 72 - N° 3
P. 485-488 - mars 2015 Retour au numéro
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