Palmoplantar pustules and osteoarticular pain in a 42-year-old woman - 15/02/15

Doi : 10.1016/j.jaad.2014.07.014

Rena C. Zuo, BA ^a, Daniella M. Schwartz, MD ^c, Chyi-Chia Richard Lee, MD, PhD ^b, Milan J. Anadkat, MD ^d, Edward W. Cowen, MD, MHSc ^a, Haley B. Naik, MD ^a,^⁎
^a Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
^b Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
^c National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland
^d Division of Dermatology, Washington University School of Medicine, St Louis, Missouri

^∗Correspondence to: Haley B. Naik, MD, Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bldg 10/Room 12N238, 10 Center Dr, MSC 1908, Bethesda, MD 20892-1908.

Abstract

Key teaching points

• Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is characterized by distinctive osteoarticular manifestations and a spectrum of neutrophilic dermatoses.

• The most common dermatologic manifestations include palmoplantar pustulosis, acne conglobata, and acne fulminans.

• SAPHO syndrome should be considered in patients presenting osteoarticular pain, particularly involving the anterior chest wall and/or spine, and neutrophilic skin lesions.

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Key words : autoinflammatory, chronic recurrent multifocal osteomyelitis, neutrophilic dermatoses, palmoplantar pustulosis, synovitis-acne-pustulosis-hyperostosis-osteitis

Abbreviations used : CRMO, IL, NIH, SAPHO

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	This research was supported by the Intramural Research Program of the National Institutes of Health (NIH), Center for Cancer Research, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases and the Medical Research Scholars Program, a public-private partnership supported jointly by the National Institutes of Health and generous contributions to the Foundation for the NIH from Pfizer Inc, the Doris Duke Charitable Foundation, the Alexandria Real Estate Equities Inc and Mr and Mrs Joel S. Marcus, and the Howard Hughes Medical Institute, as well as other private donors.
	Conflicts of interest: None declared.
	Reprints not available from the authors.

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Vol 72 - N° 3

P. 550-553 - mars 2015 Retour au numéro

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Palmoplantar pustules and osteoarticular pain in a 42-year-old woman - 15/02/15

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