French survey of the first three-years of liver transplantation activity from uncontrolled donors deceased after cardiac death - 18/03/15
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Abstract |
Objective |
To assess the first three years of French activity related to liver transplantation from uncontrolled donation after cardiac death (uDCD).
Study design |
Prospective and observational study in the three active centres authorized by the French Biomedicine Agency.
Patients and methods |
All patients deceased between 2010 and 2012 after an uncontrolled cardiac arrest admitted to one of three centres (Pitié-Salpêtrière, Saint-Louis or Bicêtre hospitals, AP–HP, Paris, France) and potentially eligible for liver recovery were included. Abdominal normothermic oxygenated recirculation (ANOR) was used for graft preservation.
Results |
One hundred twenty-six potential uDCD donors were identified as eligible for liver recovery after hospital admission. The main causes of organ recovery failure were technical failure related to ANOR (29 patients, 23%), refusal of consent (39 patients, 31% of potential uDCD donors and 40% of asked relatives) and abnormal hepatic transaminases up to 200 UI.L−1 during ANOR (24 patients, 19%). Finally, 11 livers were transplanted. Process efficiency was 9% [95% CI: 4–15%]. One-year recipient survival was 82%, [95% CI: 48–98%] and one-year graft survival was 64% [95% CI: 31–89%].
Conclusion |
Liver transplantation from uDCD donors is achievable in France, despite low process efficiency.
Le texte complet de cet article est disponible en PDF.Keywords : Liver transplant, Donation after cardiac death, Organ, Extracorporeal membranous oxygenation
Plan
Vol 34 - N° 1
P. 35-39 - février 2015 Retour au numéro
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