Cytotoxic T cells – Stroma interactions - 27/03/15
, Houssem Benlalam, Meriem Hasmim, Salem ChouaibAbstract |
The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.
Le texte complet de cet article est disponible en PDF.Key words : hypoxia, STAT3, HIF-1α, endothelial cells, tumor cells, CTLs
Plan
Vol 98 - N° 2
P. E19-E24 - février 2011 Retour au numéro
Article précédent
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