Characterization of prostate cancer using T2 mapping at 3 T: A multi-scanner study - 16/04/15
Abstract |
Rationale and objectives |
To assess the prostate T2 value as a predictor of malignancy on two different 3T scanners.
Patients and methods |
Eighty-three pre-prostatectomy multiparametric MRIs were retrospectively evaluated [67 obtained on a General Electric MRI (scanner 1) and 16 on a Philips MRI (scanner 2)]. After correlation with prostatectomy specimens, readers measured the T2 value of regions-of-interest categorized as “cancers”, “false positive lesions”, or “normal tissue”.
Results |
On scanner 1, in PZ, cancers had significantly lower T2 values than false positive lesions (P=0.02) and normal tissue (P=2×10−9). Gleason≥6 cancers had similar T2 values than false positive lesions and significantly higher T2 values than Gleason≥7 cancers (P=0.009). T2 values corresponding to a 25% and 75% risk of Gleason≥7 malignancy were respectively 132ms (95% CI: 129–135ms) and 77ms (95% CI: 74–81ms). In TZ, cancers had significantly lower T2 values than normal tissue (P=0.008), but not than false positive findings. Mean T2 values measured on scanner 2 were not significantly different than those measured on scanner 1 for all tissue classes.
Conclusion |
All tested tissue classes had similar mean T2 values on both scanners. In PZ, the T2 value was a significant predictor of Gleason≥7 cancers.
Le texte complet de cet article est disponible en PDF.Keywords : Prostate cancer, Prostate multiparametric MRI, T2, Prostate cancer aggressiveness
Plan
Vol 96 - N° 4
P. 365-372 - avril 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.