Neurotrophin receptors and perineural invasion in desmoplastic melanoma - 17/04/15
Abstract |
Background |
Perineural invasion (PNI) in desmoplastic melanoma is associated with increased local recurrence and reduced disease-free survival. The biological mechanisms underlying PNI remain unclear although several lines of evidence implicate neurotrophins and their receptors.
Objectives |
We investigated the expression of p75NGFR and TrkA, and the presence of functional RET polymorphism (RETp) as they relate to PNI in desmoplastic melanoma.
Methods |
In all, 43 cases of desmoplastic melanoma were immunohistochemically evaluated for TrkA and p75NGFR expression and RETp was detected by direct DNA sequencing.
Results |
PNI was present in 67% of cases. On univariate analysis, p75NGFR was associated with PNI (expression detected in 79% of PNI-positive cases compared with 36% of PNI-negative cases, P = .005), increased Breslow depth (P = .007), and greater Clark level (P = .01). RETp was noted in 28% of cases but was not significantly associated with PNI (P = .27) or other histopathologic variables. TrkA expression was absent in all cases. PNI was associated with increased Breslow depth and Clark level (P = .01 and P = .009, respectively). Controlling for the association between p75NGFR and depth, p75NGFR remained associated with an increased propensity for PNI (odds ratio 4.68, P = .04).
Limitations |
The sample size was limited.
Conclusion |
In desmoplastic melanoma, p75NGFR expression is significantly associated with PNI and a more locally aggressive phenotype.
Le texte complet de cet article est disponible en PDF.Key words : desmoplastic melanoma, immunohistochemistry, neurotrophin, p75NGFR, perineural invasion, RET, TrkA
Abbreviations used : IHC, NGF, OR, PNI, RETp
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 72 - N° 5
P. 851-858 - mai 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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