Genetic variants of the DNA damage repair genes XRCC4 and RAD51 are associated with susceptibility to esophageal cancer - 03/06/15
, Ju Hui-xiang, Zhou Zhong-wei, Jin Hao, Zhu RongBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 5 |
| Iconographies | 0 |
| Vidéos | 0 |
| Autres | 0 |
Summary |
Objective |
Altered DNA damage repair genes have been demonstrated to contribute to tumorigenesis. This study explored the relationship of genetic polymorphisms of the DNA repair genes XRCC4 and RAD51 to the risk of esophageal cancer.
Methodology |
Genotyping of XRCC4 G-1394T (rs6869366) and RAD51-G135C by PCR-RFLP analysis was performed on 477 participants, of whom 219 were patients with esophageal cancer; the remaining participants were healthy. Statistical analysis, including Chi2 test and logistic regression, was used to assess genotypic distributions and their correlation with cancer risk.
Results |
Carriers of the XRCC4 rs6869366 G allele (GT+GG) were at a significantly higher risk of esophageal cancer compared to individuals with the TT genotype [odds ratio (OR)=3.35, 95% confidence interval (CI): (1.16–10.24)]. Carriers of the C allele of RAD51 G135C (GC+CC) had a significantly increased risk of esophageal cancer compared to individuals with the GG genotype (OR=2.53, 95%CI: 1.15–6.70). Further, the variant genotypes of XRCC4 and RAD51 interacted to exacerbate the risk of esophageal cancer (OR=8.92, 95%CI: 2.47–38.20).
Conclusions |
Variants of the DNA damage repair genes XRCC4 and RAD51 increase the risk of esophageal cancer.
Le texte complet de cet article est disponible en PDF.Plan
Vol 39 - N° 3
P. 379-383 - juin 2015 Retour au numéro
Article précédent
- The role of serum intestinal fatty acid binding protein levels and D-lactate levels in the diagnosis of acute intestinal ischemia
- Hui Shi, Benyan Wu, Jun Wan, Wenhui Liu, Binbin Su
- Crohn's disease-specific anti-CUZD1 pancreatic antibodies are absent in ruminants with paratuberculosis
- Christos Liaskos, Vassiliki Spyrou, Labrini V. Athanasiou, Timoklia Orfanidou, Athanasios Mavropoulos, Eirini I. Rigopoulou, Georgios S. Amiridis, Yehuda Shoenfeld, Charalambos Billinis, Dimitrios P. Bogdanos
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?