Associations of Schizotypy with Prefrontal Function and Psychopathology: “positive” or “negative”? Findings From the Premes Cohort - 09/06/15
Résumé |
Introduction |
Although Positive (PS) and Negative Schizotypy (NS) are considered distinct entities, prefrontal dysfunction seems to be a common underlying mechanism. According to recent evidence, PS can be divided into Paranoid (ParS) and Cognitive-Perceptual (CPS).
Objectives |
To explore NS’, ParS’ and CPS’ profiles of prefrontal function/psychopathology/stressful childhood experiences.
Aims |
To examine associations between NS, ParS and CPS with the above phenotype in a community sample.
Methods |
140 healthy adults completed the Schizotypal-Personality Questionnaire (SPQ), Symptom-Checklist-90-Revised (SCL-90R), Wisconsin Card-Sorting Test (WCST), CANTAB Spatial Working Memory (SWM), Parental-Bonding Instrument (PBI) and Child Abuse/Trauma Scale (CAT). Associations between schizotypal dimensions and outcome variables were examined with separate forward regression-analyses (confounders: age, smoking).
Results |
High ParS and NS but not CPS were predicted by high CAT score and low parental-care respectively (Ps<0.001). High NS and high ParS predicted inefficient SWM strategy and increased WCST perseverative-errors (Ps<0.001; R2:0.155 and 0.243) while high ParS also predicted fewer WCST-completed categories and increased total errors (Ps<0.001; R2:0.138 and 0.174). All schizotypal dimensions along with reduced parental-care predicted high SCL-90 psychopathology in all dimensions (Ps<0.001); NS predicted mostly interpersonal sensitivity, depression and phobic anxiety (R2range:0.211-0.426), ParS predicted mostly obsessive-compulsive symptomatology, anxiety, paranoid ideation and psychoticism (R2range:0.257-0.373) and CPS predicted mostly somatization and anger/hostility (R2:0.240 and 0.213).
Conclusions |
ParS and NS were similar in terms of prefrontal dysfunction and childhood life experiences although they differed in their clinical psychopathology patterns. CPS seems to be a ’less severe” form of schizotypy in terms of prefrontal dysfunction and childhood experiences with minimal impact on current psychopathology.
Le texte complet de cet article est disponible en PDF.Vol 30 - N° S1
P. 199 - mars 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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