Association of Adolescent Cannabis Use and Risk of Psychosis After Adjustment with Prodromal Symptoms - 09/06/15
Résumé |
Introduction |
Recent studies have shown that cannabis use acts as a specific risk factor provoking the onset of psychosis in vulnerable individuals. Association of adolescent cannabis use and psychosis risk was studied after adjustment with prodromal symptoms.
Objectives |
To assess possible causality between cannabis use and the risk of psychosis.
Aims |
To examine associations between cannabis use and the risk of psychosis in 10 years follow-up while taking into account the prodromal symptoms of psychosis in a prospective general population sample.
Methods |
The sample (N=6258) composed of a prospective Northern Finland Birth Cohort 1986. Questionnaire on prodromal symptoms for psychosis (PROD-screen) and on drug use was conducted when the cohort members were 15-16 years old. The participants were asked if they had tried cannabis: never, once, 2-4 times, 5 times or more. Information on psychoses was gathered from registers until age 27 years.
Results |
In total 102 new psychoses emerged. The proportion of psychoses in the groups ’never”, ’once”, ’2-4 times”, ’5 times or more” were 1.5%, 2.8%, 3.6%, and 8.5%, respectively. The hazard ratio (HR) for risk of psychosis in subjects who had tried cannabis 5 times or more was 5.9 (95% CI 2.4-14.4) when compared to non-users. The association remained statistically significant when adjusted for prodromal symptoms and parental psychosis (HR 2.6, 1.0-6.6). When gender and smoking was taken into account association was no longer significant (HR 2.3, 0.9-6.0).
Conclusions |
Adolescent cannabis use associates with increased risk of first-episode psychosis even after controlling for baseline prodromal symptoms.
Le texte complet de cet article est disponible en PDF.Vol 30 - N° S1
P. 381 - mars 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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