Risk Factors of Recurrence in Major Depressive Disorders - 09/06/15
Résumé |
Introduction |
About 60 % of the subjects with a first episode of major depression will present a second episode lifetime. Thus, it is important to determine the risk factors of recurrence.
Aims |
To identify the risk factors of depressive recurrence.
Methods |
It is a retrospective study conducted in university hospital of Mahdia including 150 patients hospitalized in psychiatric ward for major depressive disorder according to DSM-IV-TR. Data were collected using a questionnaire of 89 items. Statistical analysis was done using the Kaplan-Meier method. The Cox test was used to check for recurrence risk factors.
Results |
The sample was divided into:
• | Group 1: diagnosed with major depressive disorder, single episode (MDD, n = 63) |
• | Group 2: diagnosed with recurrent major depressive disorder (MDDr, n = 87) |
Family history of mood disorders were found in 25,4% and 59,7% of patients in respectively group 1 and 2. The age of onset was less than 25 years in 34.48% of Group 2 against 22.2% in group 1. Residual symptoms were similar in both groups. The mean time to recurrence was 109 months. Multivariate analysis retained 5 risk factors: early age of onset disorders (p = 0.02), family history of mood disorder (p = 0.04), the severity of depressive index episode (p = 0.03), the persistence of residual symptoms (p = 0.02) and early interruption of the treatment (p = 0.04).
Conclusion |
The identification of risk factors for recurrence before a first depressive episode is very important to prevent recurrence and chronicity.
Le texte complet de cet article est disponible en PDF.Vol 30 - N° S1
P. 720 - mars 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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