Systemic granulocyte colony-stimulating factor (G-CSF) enhances wound healing in dystrophic epidermolysis bullosa (DEB): Results of a pilot trial - 17/06/15
Abstract |
Background |
Chronic nonhealing wounds are the norm in patients with inherited epidermolysis bullosa (EB), especially those with dystrophic EB (DEB). A possible benefit in wound healing after subcutaneous treatment with granulocyte colony-stimulating factor (G-CSF) was suggested from an anecdotal report of a patient given this during stem cell mobilization before bone-marrow transplantation.
Objective |
We sought to determine whether benefit in wound healing in DEB skin might result after 6 daily doses of G-CSF and to confirm its safety.
Methods |
Patients were assessed for changes in total body blister and erosion counts, surface areas of selected wounds, and specific symptomatology after treatment.
Results |
Seven patients with DEB (recessive, 6; dominant, 1) were treated daily with subcutaneous G-CSF (10 μg/kg/dose) and reevaluated on day 7. For all patients combined, median reductions of 75.5% in lesional size and 36.6% in blister/erosion counts were observed. When only the 6 responders were considered, there were median reductions of 77.4% and 38.8% of each of these measured parameters, respectively. No adverse side effects were noted.
Limitations |
Limitations include small patient number, more than 1 DEB subtype included, and lack of untreated age-matched control subjects.
Conclusions |
Subcutaneous G-CSF may be beneficial in promoting wound healing in some patients with DEB when conventional therapies fail.
Le texte complet de cet article est disponible en PDF.Key words : dystrophic epidermolysis bullosa, granulocyte colony-stimulating factor, therapy, wound healing
Abbreviations used : BMT, DEB, EB, G-CSF, RDEB
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 73 - N° 1
P. 56-61 - juillet 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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