Ultrasonographic assessment of liver fibrosis with computer-assisted analysis of liver surface irregularities - 07/09/15
, I. Denis b, A. Martino a, B. Gallix c, N. Sturm d, V. Leroy e, I. Bricault a, f
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Abstract |
Purpose |
The goal of this study was to evaluate the diagnostic accuracy of a software program that automatically analyzes the liver surface to diagnose significant fibrosis, by comparing it to the subjective analysis of a radiologist and to transient elastography (Fibroscan®).
Patients and methods |
One hundred fourteen patients with chronic liver disease were included in the study. They underwent liver biopsy, FibroScan® and ultrasonographic examination of the liver surface. The liver surface was analyzed by a software program that gave a score of surface irregularities. This evaluation was compared to subjective analysis by a radiologist expert in liver imaging and by two general radiologists.
Results |
Fifty percent of the patients had significant fibrosis according to the METAVIR score. The AUROC for the diagnosis of significant fibrosis by the software program was 0.80 (95%CI: 0.71–0.87), which was equivalent (P=0.86) to that of FibroScan® (0.81; 95%CI: 0.71–0.89). Results of the subjective analysis by the expert radiologist were poorer than those of the software analysis (P=0.02) (AUROC=0.66; 95%CI: 0.56–0.75). Interobserver agreement among radiologists was poor (0.25<kappa<0.37).
Conclusion |
Computer-assisted liver surface analysis was better than subjective analysis, and similar to that of the FibroScan®. This method could be useful for the diagnosis of significant fibrosis in patients with chronic hepatitis and complementary to the other non-invasive diagnostic tests.
Le texte complet de cet article est disponible en PDF.Keywords : Ultrasound, Liver fibrosis, Computer-assisted image analysis
Abbreviations : AUROC, NASH, ROC, HBV, HCV, HIV, NPV, PPV
Plan
Vol 96 - N° 9
P. 941-946 - septembre 2015 Retour au numéro
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