Association of plasma and synovial fluid periostin with radiographic knee osteoarthritis: Cross-sectional study - 07/10/15
, Vajara Wilairatana b, Wanvisa Udomsinprasert a, Peerasit Sinlapavilawan b, Napaphat Jirathanathornnukul aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objective |
To investigate plasma and synovial fluid (SF) periostin of knee osteoarthritis (OA) patients and to determine the relationship between periostin levels and the radiographic severity.
Methods |
A total of 110 subjects (90 knee OA patients and 20 healthy controls) were enrolled in this study. Plasma and SF periostin were examined using an enzyme-linked immunosorbent assay. OA grading was performed using the Kellgren-Lawrence classification.
Results |
Although plasma periostin was greater in OA patients than in controls, the difference was not significant. Additionally, SF periostin was significantly higher with respect to paired plasma (P<0.001). Moreover, plasma and SF periostin demonstrated significantly positive correlation with the radiographic severity of knee OA (r=0.537, P<0.001 and r=0.427, P<0.001, respectively). Subsequent analysis revealed that there was a positive correlation between plasma and SF periostin (r=0.368, P<0.001).
Conclusions |
Plasma and SF periostin levels were positively correlated with the radiographic severity of knee OA.
Le texte complet de cet article est disponible en PDF.Keywords : Osteoarthritis, Periostin, Plasma, Radiographic severity, Synovial fluid
Plan
Vol 82 - N° 5
P. 352-355 - octobre 2015 Retour au numéro
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