Remission of refractory pyoderma gangrenosum, severe acne, and hidradenitis suppurativa (PASH) syndrome using targeted antibiotic therapy in 4 patients - 14/10/15
Abstract |
Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance therapy is also necessary to prevent disease relapse. The response to antibiotic therapy is hypothesis generating, raising the issue of a modified host response. To date, anecdotal reports support the use of surgery and medical therapy, but controlled investigations with extended follow-up are necessary to substantiate preliminary data observed with individual cases.
Le texte complet de cet article est disponible en PDF.Key words : acne fulminans, antibiotic therapy, hidradenitis suppurativa, microbiome host disease, PASH syndrome, pyoderma gangrenosum, remission, severe acne
Abbreviations used : IV, NSAID, PASH, PG, PTA, HS
Plan
This publication was supported through funding provided by AbbVie Corporation. |
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Supported by the Fondation pour la Recherche Médicale (ROXANNE project, LMV20100519581) for the genetic portion of the study only. |
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Conflicts of interest: None declared. |
Vol 73 - N° 5S1
P. S66-S69 - novembre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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