Nevoid melanoma: A study of 43 cases with emphasis on growth pattern - 15/10/15
Abstract |
Background |
Nevoid melanoma may be confused both clinically and histologically with benign nevi.
Objective |
The aim of this study was to characterize the histologic features of nevoid melanoma.
Methods |
Forty-three cases of nevoid melanoma from our laboratory were evaluated.
Results |
Our study cases included 33 men and 10 women with mean age of 62 years. The back was the most common site followed by the arm. A clinical diagnosis other than melanoma was made in about 40% of the cases. Two architectural patterns were identified: Plaque and polypoid. Sheetlike confluence of melanocytes expanding the papillary dermis was seen in 60% of the cases. Nests disposed in parallel arrays at the base of the tumor (parallel theque pattern) were present in roughly 81% of our series. Mitoses were evident in one-third of cases ranging from less than 1 to 4 per square millimeter.
Genomic abnormalities characteristic of melanoma were detected in 7 of 8 tested cases.
Limitation |
This is a descriptive study. No follow-up information was available for 32 of the 43 patients. In the other 11, follow-up was limited to the re-excision specimens.
Conclusion |
Characteristic growth patterns including confluence of dermal melanocytes with no intervening connective tissue and the parallel theque pattern can be helpful in suggesting a diagnosis of nevoid melanoma at scanning magnification.
Le texte complet de cet article est disponible en PDF.Key words : malignancy, melanoma, melanocytic, nevoid, parallel theque, skin, tumor
Abbreviations used : aCGH, CGH, FFPE, FISH
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 73 - N° 5
P. 836-842 - novembre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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