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Bulletin du Cancer
Volume 102, n° 11
pages 946-957 (novembre 2015)
Doi : 10.1016/j.bulcan.2015.07.007
Received : 7 April 2015 ;  accepted : 10 July 2015
Prise en charge des myélodysplasies
Management of myelodysplastic syndromes
 

Matthieu Duchmann 1, Pierre Fenaux 2, Thomas Cluzeau 3, 4,
1 Institut Gustave-Roussy, service d’hématologie, 94805 Paris, France 
2 Université Paris 7, Assistance publique des Hôpitaux de Paris, hôpital Saint-Louis, service d’hématologie séniors, 75010 Paris, France 
3 Assistance publique des Hôpitaux de Paris, hôpital Saint-Louis, service d’hématologie, 75010 Paris, France 
4 Centre méditerranéen de médecine moléculaire, Inserm U1065, 06204 Nice, France 

Thomas Cluzeau, Centre méditerranéen de médecine moléculaire, Inserm U1065, bâtiment ARCHIMED, 151, route Saint-Antoine-de-Ginestière, 06204 Nice, France.
Résumé

Les syndromes myélodysplasiques sont des maladies hétérogènes, dont la caractérisation moléculaire est très récente. Une meilleure connaissance des facteurs pronostiques, l’amélioration des traitements, notamment un plus grand accès à l’allogreffe de cellules souches et l’arrivée de nouvelles molécules (les agents hypométhylants [azacitidine et décitabine] et le lénalidomide) ont amélioré la prise en charge des patients.

The full text of this article is available in PDF format.
Summary

Myelodysplastic syndromes are heterogeneous diseases whose molecular characteristics have only been identified in recent years. Better identification of prognostic factors, larger access to allogeneic stem cell transplantation and the advent of new drugs notably hypomethylating agents (azacitidine, decitabine) and lenalidomide have improved patient outcome.

The full text of this article is available in PDF format.

Mots clés : Syndromes myélodysplasiques, Traitement, Caractérisation, Moléculaire, Cytogénétique

Keywords : Myelodysplastic syndrome, Treatment, Characterization, Molecular, Cytogenetic




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