Efficacy of Tocilizumab in the treatment of Eosinophilic fasciitis: Report of one case - 24/11/15
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Abstract |
A 43-year-old man was diagnosed with an Eosinophilic fasciitis with cutaneous and articular involvement. The patient experienced an early response with high-dose corticosteroids achieving a global remission of disease. Nevertheless, during the steroids tapering phase, he presented a new flare and subsequently developed a corticosteroid refractory disease. The addition of Methotrexate in monotherapy then associated with an anti-tumor necrosis factor agent did not show any additional benefit. Therefore Tocilizumab, a humanized monoclonal antibody against the interleukin-6 receptor, was initiated achieving an immediate response that persists after 36months of follow-up. The use of this biological agent allows prednisone withdrawal at 3months and remission of both articular and cutaneous manifestations at 6months. This report describes for the first time the efficacy of an anti interleukin-6 agent in Eosinophilic fasciitis treatment.
Le texte complet de cet article est disponible en PDF.Keywords : Eosinophilic fasciitis, Corticosteroids refractory disease, Interleukin-6, Tocilizumab
Plan
Vol 82 - N° 6
P. 460-461 - décembre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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