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Journal of the American Academy of Dermatology
Volume 74, n° 1
pages 120-126 (janvier 2016)
Doi : 10.1016/j.jaad.2015.08.024
accepted : 12 August 2015
Original Articles

Increasing incidence of infantile hemangiomas (IH) over the past 35 years: Correlation with decreasing gestational age at birth and birth weight

Katelyn R. Anderson, MD a, Jennifer J. Schoch, MD a, Christine M. Lohse, MS c, Jennifer L. Hand, MD a, b, d, Dawn M. Davis, MD a, b, Megha M. Tollefson, MD a, b,
a Department of Dermatology, Mayo Clinic, Rochester, Minnesota 
b Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 
c Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota 
d Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota 

Reprint requests: Megha M. Tollefson, MD, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

Infantile hemangiomas (IH) are the most common soft-tissue tumors of infancy, but little is known regarding their true incidence.


We sought to determine the current incidence of IH and examine trends in incidence, demographics, and lesion characteristics over 3 decades.


The Rochester Epidemiology Project was used to identify infants residing in Olmsted County, Minnesota, who were given a diagnosis of IH between January 1, 1976, and December 31, 2010.


In all, 999 infants were given a diagnosis of IH. Incidence increased over the 3-decade study period from 0.97 to 1.97 per 100 person-years (P  < .001). Average gestational age at birth and birth weight for infants with IH decreased over the study period (39.2-38.3 weeks, P  < .001 and 3383-3185 g, P  = .003, respectively). The overall age- and sex-adjusted incidence of IH was 1.64 per 100 person-years (95% confidence interval 1.54-1.75).


The population of Olmsted County, Minnesota, is predominantly non-Hispanic white, limiting our ability to report racial differences in incidence. This was a retrospective study.


This study provides a longitudinal, population-based incidence of IH. Incidence has increased steadily over the past 3 decades, correlating significantly with decreasing gestational age at birth and birth weight in affected infants.

The full text of this article is available in PDF format.

Key words : hemangioma, incidence, infantile hemangioma, vascular anomaly, vascular birthmark, vascular tumor

 Drs Anderson and Schoch contributed equally in this research.
 Funding sources: Rochester Epidemiology Project NIH grant (NIH R01 AG034676).
 Conflicts of interest: None declared.

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