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Journal of the American Academy of Dermatology
Volume 74, n° 2
pages 333-340 (février 2016)
Doi : 10.1016/j.jaad.2015.09.047
accepted : 22 September 2015
Original Articles

Other primary systemic cancers in patients with melanoma: Analysis of balanced acral and nonacral melanomas
 

Soo Hyeon Bae, MD a, , Hyun Ju Seon, MD, PhD b, Yoo Duk Choi, MD, PhD c, Hyun-Jeong Shim, MD, PhD d, Jee-Bum Lee, MD, PhD a, Sook Jung Yun, MD, PhD a
a Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea 
b Department of Radiology, Chonnam National University Medical School, Gwangju, Korea 
c Department of Pathology, Chonnam National University Medical School, Gwangju, Korea 
d Department of Oncology, Chonnam National University Medical School, Gwangju, Korea 

Reprint requests: Sook Jung Yun, MD, PhD, Department of Dermatology, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju 501-746, Korea (South).
Abstract
Background

Although other primary systemic cancers in patients with melanoma have been studied, there have been few focusing on acral melanomas.

Objectives

We assessed other primary systemic cancers in patients with acral and nonacral melanomas.

Methods

We analyzed other primary cancers in 452 patients with melanoma from 1994 to 2013. Metachronous cancers were defined as those given a diagnosis more than 2 months after diagnosis of melanoma. The others were considered prechronous or synchronous cancers.

Results

Among 51 cases of other primary cancers, gastrointestinal cancer (35.3%, n = 18/51) was the most common, followed by thyroid (17.6%), lung (11.8%), and breast (5.9%). Those were more prevalent in the acral melanoma group (12.8%, n = 31/243) compared with the nonacral melanoma group (9.6%, n = 20/209). Of 23 cases of metachronous cancer, the risk was the highest in bone marrow, followed by oral cavity, bladder, colon, lung, and thyroid. Among 28 cases of prechronous or synchronous cancers, gastrointestinal tract (35.7%, n = 10/28) was the most common site, followed by thyroid (17.9%), breast (10.7%), and lung (7.1%).

Limitations

The study is limited by a small number of patients.

Conclusion

Careful follow-up and imaging studies are necessary for early detection of other primary cancers and metastatic lesions in patients with melanoma.

The full text of this article is available in PDF format.

Key words : acral melanoma, metachronous cancer, nonacral melanoma, other primary systemic cancer, prechronous or synchronous

Abbreviations used : ALM, CI, NMSC, SIR, SSM



 Drs Soo Hyeon Bae and Hyun Ju Seon contributed equally to all aspects of this article.
 This study was supported by a grant (HCRI 15 016-21) from Chonnam National University Hwasun Hospital Institute for Biomedical Science and by Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology (2011-0030034).
 Conflicts of interest: None declared.



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