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Joint Bone Spine
Volume 83, n° 2
pages 155-159 (mars 2016)
Doi : 10.1016/j.jbspin.2015.11.005
accepted : 4 February 2015
Influenza and pneumococcal vaccine coverage in 584 patients taking biological therapy for chronic inflammatory joint: A retrospective study

Olivier Brocq a, , Emilie Acquacalda b, Frédéric Berthier c, Christine Albert b, Gilles Bolla d, Elodie Millasseau e, Claire Destombe e, Johanna Azulay d, Caroline Asquier d, Amélie Florent b, Sylvie Le Seaux e, Liana Euller-Ziegler b
a Rhumatologie, centre hospitalier Princesse Grâce, boulevard Pasteur, 98000 Monaco, Monaco 
b Service de rhumatologie, hôpital Archet 1, université de Nice, 06200 Nice, France 
c Département d’information médicale, CHPG, 98000 Monaco, Monaco 
d Service de rhumatologie, centre hospitalier de Cannes, 06400 Cannes, France 
e Service de rhumatologie, centre hospitalier Fréjus-Saint-Raphaël, 83800 Saint-Raphaël, France 

Corresponding author.

To evaluate influenza and pneumococcal vaccine coverage in patients taking biological therapy for chronic inflammatory joint disease and to identify factors associated with the decision to administer these two vaccines.


Retrospective cross-sectional questionnaire study of a cohort of 584 patients taking biological therapy for chronic inflammatory joint disease (rheumatoid arthritis or spondyloarthritis). We studied the influenza and pneumococcal vaccine coverage rates, information about these vaccines given to patients by the primary-care physician and rheumatologist, and reasons for not administering the vaccines.


Overall vaccine coverage rates were 44% for influenza and 62% for pneumococcus. Factors associated with being vaccinated were patient age, previous influenza vaccination, and patient information. Concern about adverse effects and absence of patient information by the primary-care physician and rheumatologist were associated with very low coverage rates.


This study showed insufficient vaccine coverage rates, particularly against influenza, in a population at high risk because of exposure to biological therapy. Patient information by healthcare professionals about influenza and pneumococcal vaccination has a major impact and should be renewed as often as possible.

The full text of this article is available in PDF format.

Keywords : Influenza vaccination, Pneumococcal vaccination, Biological therapy, Chronic inflammatory joint disease

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