Paradoxical anti-TNF-associated TB worsening: Frequency and factors associated with IRIS - 05/03/16
for
the RATIO Group2
pages | 6 |
Iconographies | 0 |
Vidéos | 0 |
Autres | 0 |
Abstract |
Objectives |
Paradoxical tuberculosis (TB) worsening, an example of the immune reconstitution inflammatory syndrome (IRIS), is an increasing phenomenon now described in several settings, including anti-tumor necrosis factor (TNF) discontinuation during biotherapy-induced TB. To better recognize it, we analyzed the frequency and factors associated with anti-TNF-induced TB–IRIS.
Methods |
Case-control study on anti-TNF-associated TB patients. IRIS cases, defined with the following consensus criteria, were matched to two controls (anti-TNF-associated TB without IRIS). IRIS frequency was based on the French RATIO registry. Conditional logistic-regression identified IRIS risk factors.
Results |
Fourteen patients developed anti-TNF-associated TB–IRIS within medians of 45 [IQR 22–131] days after starting anti-TB therapy and 110 [IQR 63–164] days after the last anti-TNF infusion. Each case was matched to two controls by year of TB diagnosis. IRIS-associated factors were (odds ratio [95% CI]): disseminated TB (11.4 [1.4–92.2], P=0.03), history of Mycobacterium tuberculosis exposure (12.7 [1.6–103.0], P=0.02) and steroid use at the time of TB diagnosis (4.6 [1.2–17.2], P=0.02). The RATIO registry IRIS frequency was 7%.
Conclusion |
After stopping biotherapy, paradoxical anti-TNF-associated TB worsening occurred most often in patients with disseminated TB. Although diagnosis remains difficult, physicians must be aware of IRIS because prolonged anti-TB treatment is not needed but, paradoxically, immunosuppressant reintroduction may be.
Le texte complet de cet article est disponible en PDF.Keywords : TNF-blockers, Tuberculosis, IRIS
Plan
Vol 83 - N° 2
P. 173-178 - mars 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?