Distinguishing diffuse alopecia areata (AA) from pattern hair loss (PHL) using CD3+ T cells - 14/04/16
, Curtis Thompson, MD bAbstract |
Background |
Distinguishing between diffuse subacute alopecia areata (AA), in which the peribulbar infiltrate is absent, and pattern hair loss is challenging, particularly in cases that lack marked follicular miniaturization and a marked catagen/telogen shift.
Objective |
We sought to distinguish diffuse AA from pattern hair loss using CD3+ T lymphocytes.
Methods |
A total of 28 cases of subacute AA and 31 cases of pattern hair loss were selected and a 4-mm punch biopsy was performed. All the specimens were processed using the “HoVert” (horizontal and vertical) technique. In all cases, hematoxylin-eosin and immunohistochemical stains for CD3, CD4, CD8, and CD20 were performed.
Results |
The presence of CD3+ lymphocytes within empty follicular fibrous tracts (stela), even without a concomitant peribulbar infiltrate, is a reliable histopathological clue in supporting a diagnosis of AA (sensitivity 0.964, specificity 1, P ≤ .001).
Limitations |
Limited tissue for analysis remained in the clinical sample tissue blocks.
Conclusion |
The presence of CD3+ T-cells within empty follicular fibrous tracts (stela) supports a diagnosis of AA.
Le texte complet de cet article est disponible en PDF.Key words : alopecia areata, CD3, follicular fibrous tracts, pattern hair loss, stela
Abbreviations used : AA, AAI, CTE, PHL, T:V
Plan
| The Biostatistics and Design Program of Oregon Clinical and Translational Research Institute is supported by a grant (#UL1TR000128) from the National Center for Advancing Translational Sciences at the National Institutes of Health (NIH). The content of this study is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. |
|
| Conflicts of interest: None declared. |
Vol 74 - N° 5
P. 937-944 - mai 2016 Retour au numéro
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