A novel method for a fast diagnosis of septic arthritis using mid infrared and deported spectroscopy - 03/05/16
, Valérie Monbet c, d, e, Anne Jolivet-Gougeon f, Nadia Fatih g, Maëna Le Corvec g, h, Malik Seck c, Frédéric Charpentier g, Guillaume Coiffier a, b, Catherine Boussard-Pledel i, Bruno Bureau i, Pascal Guggenbuhl a, b, c, Olivier Loréal b, cBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objective |
To assess the ability of mid infrared deported spectroscopy to discriminate synovial fluids samples of septic arthritis patients from other causes of joint effusion.
Methods |
Synovial fluids obtained from patients with clinically suspected arthritis were collected, analysed and classified according to standard diagnostic procedures as septic or non-septic. A spectroscopic analysis on synovial fluid samples was then performed using a coiled optical fiber made with chalcogenide glass. After a factorial analysis of the normalized spectra and the computation of a Fisher test used to select the most relevant components, a logistic regression model was fitted, allowing to attribute a score between 0 – non-septic –, and 1 – septic.
Results |
In a first phase, we analysed the synovial fluids from 122 different synovial fluids including 6 septic arthritis among arthritis of various origins. Septic synovial fluids were identified with a sensitivity of 95.8% and a specificity of 93.9% and an AUROC of 0.977. The analysis of an independent set of samples (n=42, including two septic arthritis) gave similar values.
Conclusions |
Our data strongly supports the interest of mid infrared deported spectroscopy, which could be used potentially at point of care, for a rapid and easy diagnosis of septic arthritis. Now, the precision of the diagnosis must be evaluated through a multicentric study on a larger panel of patients.
Le texte complet de cet article est disponible en PDF.Keywords : Deported mid infrared spectroscopy, Synovial fluid, Arthritis, Infectious, Diagnosis
Plan
Vol 83 - N° 3
P. 318-323 - mai 2016 Retour au numéro
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