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Journal of the American Academy of Dermatology
Volume 74, n° 6
page 1073 (juin 2016)
Doi : 10.1016/j.jaad.2015.11.024
accepted : 9 November 2015
Original Articles

Assessing the clinical effectiveness of an algorithmic approach for mucosal lichen planus (MLP): A retrospective review
 

Kurt A. Ashack, MHS, BA a, Laura L. Haley, BS a, Chelsea A. Luther, BS a, Christie A. Riemer, BS a, Richard J. Ashack, MD, MS a, b,
a Michigan State University College of Human Medicine, Grand Rapids, Michigan 
b Dermatology Associates of West Michigan, Grand Rapids, Michigan 

Reprint requests: Richard J. Ashack, MD, MS, Dermatology Associates of West Michigan, 655 Kenmoor SE, Suite 200, Grand Rapids, MI 49546.Dermatology Associates of West Michigan655 Kenmoor SE, Suite 200Grand RapidsMI49546
Abstract
Background

Mucosal lichen planus (MLP) is a therapeutic challenge in need of a new treatment approach because of its debilitating effect on patient's quality of life.

Objective

We sought to evaluate a standardized treatment plan for patients with MLP. A second objective was to describe the effect of mycophenolate mofetil in this patient population.

Methods

The study retrospectively analyzed 53 patients with MLP treated using a standardized algorithm. The number of MLP lesions, disease activity, and pain at the last visit were compared with baseline scores determined at the initial visit. Results were analyzed using the paired samples t test and confirmed with the Wilcoxon matched pairs signed rank test.

Results

The average number of lesions was reduced from 3.77 to 1.67 (P  < .001). The average disease activity was reduced from 2.73 to 0.90 (P  < .001). Average pain reported decreased from 2.03 to 1.03 (P  < .001).

Limitations

This study was a retrospective analysis of a small patient population. There was no universal symptom severity scale used at the time of treatment for some patients.

Conclusion

The standardized treatment plan reduced symptoms for patients with MLP. Mycophenolate mofetil appears to be a reasonable treatment option for these patients.

The full text of this article is available in PDF format.

Key words : autoimmune disorder, mucosal lichen planus, mycophenolate mofetil, oral lichen planus, treatment algorithm, vaginal lichen planus



 Funding sources: None.
 Conflicts of interest: None declared.



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