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Science & Sports
Volume 31, n° 3
pages 152-157 (juin 2016)
Doi : 10.1016/j.scispo.2016.03.003
Received : 29 April 2015 ;  accepted : 8 Mars 2016
The effects of combined training on bone metabolic markers in postmenopausal women
Les effets d’un entraînement combiné sur les marqueurs du métabolisme osseux chez la femme post-ménopausée

A. Pereira a, b, , A.M. Costa b, c, d, A. Palmeira-de-Oliveira d, e, f, J. Soares b, g, M. Monteiro b, h, J.H.H. Williams i
a School of Education, Polytechnic Institute of Setubal, Setúbal, Portugal 
b Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), Vila Real, Portugal 
c Department of Sport Sciences, University of Beira Interior, Covilhã, Portugal 
d Health Sciences Research Centre (CICS-UBI), Covilhã, Portugal 
e Faculty of Health Science, University of Beira Interior, Covilhã, Portugal 
f Health Products Research and Development (Labfit – HPRD), Covilhã, Portugal 
g Department of Sport Sciences, Exercise and Health, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal 
h School of Education, Polytechnic Institute of Bragança, Bragança, Portugal 
i Chester Center for Stress Research, Institute of Medicine, University of Chester, UK 

Corresponding author. School of education at the polytechnic, institute of Setúbal, 2910-504 Setúbal, Cidesd Vila Real, Portugal.

Exercise plays an important role in maximizing and subsequent reduction of the maximum rates of bone loss. The purpose of this study was to determine whether 16 weeks of combined exercise in postmenopausal would affect bone metabolism.

Equipment and methods

Eleven participants (53.1 [±4.0] years) performed combined training that consisted of 60–75% of 1 RM, 2–3 sets of 10–15 repetitions in specific machines and 20–30min of cardiovascular exercises using an step platform (55–80% FCreserve). Cross-linked N-terminal telopeptides of type I collagen (NTX) was used to analyze bone resorption and serum alkaline phos-phatase (ALP) to analyze bone absorption.


After the training period, postmenopausal significantly (P <0.05) increase their muscle functionality (14% to 26.5%). Levels of NTX were not affected but there was a significant increase in bone synthesis (ALP: 12.5% to 15.9%), while there is no change in bone resorption. Combined training appears to be useful in improving total muscular performance and potentially in bone density.

The full text of this article is available in PDF format.

L’exercice joue un rôle important dans l’optimisation et la réduction subséquente des taux maximales de la perte osseuse. Cette étude avait comme objectif déterminer si après 16 semaines d’exercice combiné, en postménopause, le métabolisme osseux serait affecté.

Matériel et méthodes

Onze participants (53,1 [±4,0] ans) ont réalisé une formation combinée composée de 60–75 % de 1RM, 2–3 séries de 10–15, reproduite dans des machines spécifiques, et 20–30min d’exercices cardiovasculaires utilisant un step fitness (55–80 % FCreserve). Un réticulé télopeptides N-terminal du collagène de type I (NTX) a été utilisé pour analyser la réabsorption des os et sérum alcaline phos-phatase (ALP) pour analyser l’absorption de l’os.


Après la période de formation, les femmes post-ménopausées ont vu la fonctionnalité des muscles augmenter significativement (p <0,05) (14–26,5 %). Les niveaux de NTX n’ont pas été affectés, mais il y avait une augmentation significative de la synthèse osseuse (ALP : 12,5–15,9 %), alors qu’il n’y a aucun changement dans la réabsorption osseuse. La formation combinée semble être utile dans l’amélioration de la performance musculaire totale et, potentiellement, dans l’augmentation de la densité osseuse.

The full text of this article is available in PDF format.

Keywords : Exercise, Bone formation marker, Post-menopausal women

Mots clés : Exercice, Le marqueur de la formation osseuse, Les femmes post-ménopausées

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