Cardiovascular risk in patients with alopecia areata (AA): A propensity-matched retrospective analysis - 21/06/16
Abstract |
Background |
The cardiovascular risk of patients with alopecia areata (AA) is not well characterized, with limited studies evaluating the risk of acute myocardial infarction (AMI) and ischemic stroke.
Objective |
We sought to determine the risk for patients with AA to develop subsequent stroke and AMI.
Methods |
We conducted propensity-matched retrospective analysis between January 1, 2000, and January 1, 2010, from Brigham and Women's Hospital and Massachusetts General Hospital in Boston, MA. A comprehensive research patient data repository search was done for International Classification of Diseases, Ninth Revision code 704.01 and cases were verified using a natural language processing program. Propensity score matching was used to identify controls for AA cases based on age, race, gender, smoking status, and history of hypertension, diabetes, and hyperlipidemia.
Results |
We identified 1377 cases of AA matched with 4131 controls. Patients with AA had decreased odds for developing stroke (odds ratio 0.39, 95% CI 0.18-0.87) and a trend toward decreased risk of AMI (odds ratio 0.91, 95% CI 0.59-1.39).
Limitations |
This was a retrospective study using a clinical database.
Conclusion |
Patients with AA had decreased risk for stroke and AMI, although not statistically significant. Further studies are needed to confirm these findings in other AA cohorts and to elucidate a potential mechanism.
Le texte complet de cet article est disponible en PDF.Key words : alopecia, alopecia areata, cardiovascular risk, metabolic risk, myocardial infarction, stroke
Abbreviations used : AA, AMI, ICD-9, MTERMS, RPDR
Plan
Funding sources: None. |
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Disclosure: Dr Joyce is employed by Walgreens Co. Drs Huang, Topaz, and Mostaghimi, and Mr Guo have no conflicts of interest to declare. |
Vol 75 - N° 1
P. 151-154 - juillet 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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