Cutaneous manifestations of IgG4-related disease (RD): A systematic review - 21/06/16
Abstract |
Background |
IgG4-related disease (RD) is a recently described fibroinflammatory condition with both cutaneous and systemic manifestations. To our knowledge, the cutaneous manifestations have not been well characterized or systematically investigated to date in the literature.
Objective |
We sought to describe the cutaneous manifestations of IgG4-RD to guide clinical practice, aid in the diagnosis of IgG4-RD, and contribute to the creation of robust cutaneous diagnostic criteria.
Methods |
A systematic search of peer-reviewed publications pertaining to cutaneous manifestations of IgG4-RD yielded 56 cases from 32 case reports and series. The clinical findings among the diagnostic categories were compared.
Results |
Forty cases of IgG4-RD with cutaneous disease were identified. Cutaneous head and neck involvement was significantly associated with a diagnosis of IgG4-RD (P = .02). Macules and bullae were not described in any of the included cases. Among cases of systemic IgG4-RD, cutaneous head and neck involvement was most common and statistically significantly associated with the diagnosis of IgG4-RD (P = .001).
Limitations |
These findings are limited by reporting and publication bias of particular cases and by small sample size.
Conclusions |
Papules, plaques, and nodules of the head and neck appear to characterize patients with cutaneous IgG4-RD, which nevertheless usually presents with systemic manifestations.
Le texte complet de cet article est disponible en PDF.Key words : cutaneous manifestations, diagnosis, fibroinflammatory, hyper-IgG4 disease, IgG4-related disease, IgG4-related sclerosing disease, IgG4-related systemic disease, lymphoplasmacytic infiltrate
Plan
Drs Charrow and Imadojemu contributed equally and are co-first authors. |
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Funding sources: None. |
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Disclosure: Dr Takeshita has a grant from Pfizer and received payment for CME work related to psoriasis. Dr Lipoff received a Pfizer Independent Grant for Learning and Change from the American Academy of Dermatology. Drs Charrow, Imadojemu, and Ogunleye have no conflicts of interest to declare. |
Vol 75 - N° 1
P. 197-202 - juillet 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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