The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP) - 21/06/16
Abstract |
Background |
Herpes zoster is a common condition that causes significant morbidity.
Objective |
This study determined the incidence of zoster in patients with cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).
Methods |
In this retrospective cohort study the electronic medical records of 186 patients with CLE, 103 with DM, 83 with PV, 44 with BP, and 152 healthy control patients were reviewed to confirm positive diagnoses of zoster.
Results |
The incidence of zoster per 1000 person-years was 29.4 in CLE, 55.4 in DM, 18.6 in PV, 10.2 in BP, and 3.9 in healthy control subjects. The mean age (SD) in years was 46.1 (14.9) for CLE, 52.2 (14.5) for DM, 51.8 (13.5) for PV, 71.44 (11.8) for BP, and 48.2 (18.2) for healthy control subjects. The incidence of zoster was significantly higher in the CLE (P = .0177) and DM (P = .0070) groups than the healthy control subjects, all of whom were of a similar mean age.
Limitations |
The limitations of this study are the sample size, referral bias, and retrospective nature.
Conclusion |
The incidence of zoster in patients with CLE and, particularly, DM was significantly higher than that of the healthy control subjects.
Le texte complet de cet article est disponible en PDF.Key words : autoimmune disease, bullous pemphigoid, cutaneous lupus erythematosus, dermatomyositis, herpes zoster, pemphigus vulgaris, shingles
Abbreviations used : BP, CLE, DM, EMR, PV
Plan
| This material is based on work supported by the Department of Veterans Affairs (Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development, Merit Review 5 I01 BX000706-04); the National Institutes of Health (NIH) (NIH K24-AR 02207 and NIH R21 AR066286) to Dr Werth. |
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| Conflicts of interest: None declared. |
Vol 75 - N° 1
P. 42-48 - juillet 2016 Retour au numéro
Article précédent
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