Paraneoplastic syndromes (PNS) associated with Merkel cell carcinoma (MCC): A case series of 8 patients highlighting different clinical manifestations - 17/08/16
Abstract |
Background |
Paraneoplastic syndromes (PNS) are commonly associated with neuroendocrine cancers, such as small cell lung cancer.
Objectives |
We examined the association of PNS in Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer.
Methods |
We identified PNS associated with MCC based on chart review of a Seattle-based repository and examined the incidence of MCC-associated hyponatremia in an independent cohort within Kaiser Permanente Northern California.
Results |
Eight PNS cases were identified from the Seattle repository. Three distinct PNS types were observed: cerebellar degeneration (1 case), Lambert-Eaton myasthenic syndrome (2 cases), and malignancy-associated hyponatremia (5 cases). Moreover, the incidence of severe hyponatremia (serum sodium <125 mmol/L) coincident with MCC was identified among 4.3% (9 of 211) patients with MCC in the Kaiser Permanente Northern California cohort.
Limitations |
We did not have access to complete medical records on all patients so it was not possible to determine the prevalence of PNS in MCC.
Conclusions |
MCC can be associated with PNS similar to those found in other neuroendocrine cancers. Clinicians should be aware of these presentations as PNS often precede the identification of the underlying malignancy and usually resolve with appropriate treatment of the cancer.
Le texte complet de cet article est disponible en PDF.Key words : cerebellar degeneration, Lambert-Eaton myasthenic syndrome, malignancy-associated hyponatremia, Merkel cell carcinoma, neuroendocrine, paraneoplastic syndrome
Abbreviations used : KPNC, LEMS, MCC, PNS, SCLC, SIADH
Plan
| Supported by the American Cancer Society RSG-08-115-01-CCE, NIH-RC2-CA147820-01, NIH-K24-CA139052-0, NIH-R01-162522, David and Rosalind Bloom Endowment for Merkel Cell Carcinoma Research, Michael Piepkorn Endowment, and University of Washington Merkel Cell Carcinoma Patient Gift Fund. |
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| Disclosure: Dr Asgari received grant funding from Valeant Pharmaceuticals and Pfizer Inc, which are not relevant to this work. Drs Iyer, Bhatia, Tarabadkar, Blom, McKenzie, and Nghiem, and Mr Doumani and Parvathaneni have no conflicts of interest to declare. |
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| Conflicts of interest: None declared. |
Vol 75 - N° 3
P. 541-547 - septembre 2016 Retour au numéro
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