Association of insulin-like growth factor (IGF)-1 gene polymorphisms with plasma levels of IGF-1 and acne severity - 18/09/16
, Sanjeev Handa, MD a, Arnab Pal, MD, PhD b, Naresh Sachdeva, PhD c, Tulikalipi Ghosh, MD b, Parul Kamboj, MSc bAbstract |
Background |
Polymorphisms of the insulin-like growth factor (IGF)-1 gene consisting of variable cytosine adenosine repeats in the promoter region may directly influence the expression of IGF-1.
Objective |
We sought to assess the role of IGF-1 gene polymorphisms in determination of plasma IGF-1 levels, acne, and its severity.
Methods |
In this case-control study, 80 patients with acne vulgaris of 4 severity grades as per Global Acne Grading System and 80 age- and gender-matched control subjects without acne were studied. All the study subjects were without any disorder or a history of drug intake likely to affect IGF-1 level within a year before the study inclusion date. IGF-1 polymorphism was determined by polymerase chain reaction and plasma levels of IGF-1 by enzyme-linked immunosorbent assay. Acne severity was assessed by Global Acne Grading System.
Results |
Mean plasma IGF-1 level in acne cases was significantly higher than in non-acne controls (P = .04). Plasma IGF-1 level positively correlated with severity of acne (P = .01). Individuals homozygous for the 192-base pair (bp) allele had 4.29 times odds risk (95% confidence interval 1.38-13.33) of having acne and a significantly higher mean level of IGF-1 compared with non-192/non-192 participants. Individuals homozygous for the 192-bp allele had 3.08 times odds risk (95% confidence interval 1.15- 8.31) of having higher severity grade of acne compared with non-192/non-192 participants.
Limitations |
A relatively small number of participants were studied.
Conclusions |
Plasma IGF-1 levels positively correlate with severity of acne. The 192/192 homozygotes had higher risk of acne and higher severity grade of acne. Functional studies showing the relationship between IGF-1 promoter level polymorphism and actual gene expression in skin are warranted.
Le texte complet de cet article est disponible en PDF.Key words : acne, acne severity, insulin-like growth factor-1, polymorphism
Abbreviations used : ANOVA, bp, CA, CI, GAGS, IGF, IGFBP, OR
Plan
| Partially funded by Indian Council of Medical Research (financial assistance to MD thesis program, Grant no. 3/2/2012/PG- thesis-HRD-21 dated August 29, 2013). |
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| Conflicts of interest: None declared. |
Vol 75 - N° 4
P. 768-773 - octobre 2016 Retour au numéro
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