HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomy: A prospective case series - 15/10/16
, Sigrun L. Sigurdardottir, PhD b, Bardur Sigurgeirsson, MD, PhD a, Jon H. Olafsson, MD, PhD a, Hannes Petersen, MD, PhD c, Martin I. Sigurdsson, MD, PhD d, Johann E. Gudjonsson, MD, PhD f, Andrew Johnston, PhD f, Helgi Valdimarsson, MD, FRCP bAbstract |
Background |
Carriage of the HLA-Cw*0602 allele is associated with a particular set of clinical features and treatment responses in psoriasis. Tonsillectomy can improve psoriasis.
Objectives |
We sought to evaluate whether HLA-Cw*0602 predicts a favorable outcome after tonsillectomy of patients with psoriasis.
Methods |
This prospective case series followed up 28 tonsillectomized patients with plaque psoriasis for 24 months. The Psoriasis Area and Severity Index, Psoriasis Disability Index, and Psoriasis Life Stress Inventory were used for assessment. Tonsils were swabbed for bacteria and patients genotyped for HLA-Cw*0602.
Results |
After tonsillectomy, HLA-Cw*0602 homozygotes showed significantly more improvement, compared with heterozygous and HLA-Cw*0602–negative patients. Thus, Psoriasis Area and Severity Index score was reduced by 82% in the homozygous patients compared with 42% and 31%, respectively (P < .001), Psoriasis Disability Index score improved by 87% compared with 38% and 41%, respectively (P < .001), and Psoriasis Life Stress Inventory score was 82% reduced compared with 60% and 54%, respectively (P < .001). The homozygotes more often had psoriasis onset associated with a throat infection (P = .007) and an increased frequency of streptococcal throat infections per lifetime (P = .038).
Limitations |
Few patients were included and some data were retrospective.
Conclusions |
Homozygous HLA-Cw*0602 carriage in plaque psoriasis may predict a favorable outcome after tonsillectomy.
Le texte complet de cet article est disponible en PDF.Key words : chronic plaque psoriasis, HLA-Cw*0602, Psoriasis Disability Index, Psoriasis Life Stress Inventory, sore throat, streptococcal throat infection, tonsillectomy
Abbreviations used : PASI, PDI, PLSI
Plan
| The Icelandic Research Fund and Landspitali University Hospital Research Fund supported this study. Dr Johnston is supported by the National Institutes of Health (NIH) K01 AR064765, National Psoriasis Foundation USA, and Babcock Memorial Trust. Dr Gudjonsson is supported by NIH K08 AR060802, R01 AR069071, the A. Alfred Taubman Medical Research Institute as the Kenneth and Frances Eisenberg Emerging Scholar Award, and a Doris Duke Charitable Foundation Grant (no. 2013106). |
|
| Conflicts of interest: None declared. |
Vol 75 - N° 5
P. 889-896 - novembre 2016 Retour au numéro
Article précédent
- Direct-to-consumer teledermatology services for pediatric patients: Room for improvement
- Alexander L. Fogel, Joyce Teng, Kavita Y. Sarin
- Effects of tofacitinib on cardiovascular risk factors and cardiovascular outcomes based on phase III and long-term extension data in patients with plaque psoriasis
- Jashin J. Wu, Bruce E. Strober, Peter R. Hansen, Ole Ahlehoff, Alexander Egeberg, Abrar A. Qureshi, Debbie Robertson, Hernan Valdez, Huaming Tan, Robert Wolk
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?